Photoreceptor cKO of OTX2 Enhances OTX2 Intercellular Transfer in the Retina and Causes Photophobia

In the mature mouse retina, Otx2 is expressed in both retinal pigmented epithelium (RPE) and photoreceptor (PR) cells, and Otx2 knock-out (KO) in the RPE alone results in PR degeneration. To study the cell-autonomous function of OTX2 in PRs, we performed PR-specific Otx2 KO (cKO) in adults. As expec...

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Detalles Bibliográficos
Autores principales: Pensieri, Pasquale, Mantilleri, Annabelle, Plassard, Damien, Furukawa, Takahisa, Moya, Kenneth L., Prochiantz, Alain, Lamonerie, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496205/
https://www.ncbi.nlm.nih.gov/pubmed/34475267
http://dx.doi.org/10.1523/ENEURO.0229-21.2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496205/
https://www.ncbi.nlm.nih.gov/pubmed/34475267
http://dx.doi.org/10.1523/ENEURO.0229-21.2021

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