Generation of inducible pluripotent stem cell lines from Alzheimer’s disease patients with APOE e3/e3 genotype

iPSCs were generated from B lymphocytes of two Alzheimer’s disease (AD) patients homozygous for the APOE e3 allele. The iPSCs express pluripotency-specific markers and have the capacity to differentiate into all three embryonic germ layers. Karyotyping analyses confirmed the iPSCs have normal karyot...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jihye, Liu, Zhong, Tusing, Ying Gai, Li, Chao, Westin, Erik, Li, Wei, Zhao, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496340/
https://www.ncbi.nlm.nih.gov/pubmed/34392011
http://dx.doi.org/10.1016/j.scr.2021.102498
Descripción
Sumario:iPSCs were generated from B lymphocytes of two Alzheimer’s disease (AD) patients homozygous for the APOE e3 allele. The iPSCs express pluripotency-specific markers and have the capacity to differentiate into all three embryonic germ layers. Karyotyping analyses confirmed the iPSCs have normal karyotypes. These iPSCs can be utilized as an in vitro model to study AD and to evaluate efficacies of new treatments.

Ejemplares similares