Generation of inducible pluripotent stem cell lines from Alzheimer’s disease patients with APOE e3/e3 genotype

iPSCs were generated from B lymphocytes of two Alzheimer’s disease (AD) patients homozygous for the APOE e3 allele. The iPSCs express pluripotency-specific markers and have the capacity to differentiate into all three embryonic germ layers. Karyotyping analyses confirmed the iPSCs have normal karyot...

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Autores principales: Lee, Jihye, Liu, Zhong, Tusing, Ying Gai, Li, Chao, Westin, Erik, Li, Wei, Zhao, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496340/
https://www.ncbi.nlm.nih.gov/pubmed/34392011
http://dx.doi.org/10.1016/j.scr.2021.102498
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author Lee, Jihye
Liu, Zhong
Tusing, Ying Gai
Li, Chao
Westin, Erik
Li, Wei
Zhao, Rui
author_facet Lee, Jihye
Liu, Zhong
Tusing, Ying Gai
Li, Chao
Westin, Erik
Li, Wei
Zhao, Rui
author_sort Lee, Jihye
collection PubMed
description iPSCs were generated from B lymphocytes of two Alzheimer’s disease (AD) patients homozygous for the APOE e3 allele. The iPSCs express pluripotency-specific markers and have the capacity to differentiate into all three embryonic germ layers. Karyotyping analyses confirmed the iPSCs have normal karyotypes. These iPSCs can be utilized as an in vitro model to study AD and to evaluate efficacies of new treatments.
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spelling pubmed-84963402021-10-07 Generation of inducible pluripotent stem cell lines from Alzheimer’s disease patients with APOE e3/e3 genotype Lee, Jihye Liu, Zhong Tusing, Ying Gai Li, Chao Westin, Erik Li, Wei Zhao, Rui Stem Cell Res Article iPSCs were generated from B lymphocytes of two Alzheimer’s disease (AD) patients homozygous for the APOE e3 allele. The iPSCs express pluripotency-specific markers and have the capacity to differentiate into all three embryonic germ layers. Karyotyping analyses confirmed the iPSCs have normal karyotypes. These iPSCs can be utilized as an in vitro model to study AD and to evaluate efficacies of new treatments. 2021-08-10 2021-08 /pmc/articles/PMC8496340/ /pubmed/34392011 http://dx.doi.org/10.1016/j.scr.2021.102498 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Lee, Jihye
Liu, Zhong
Tusing, Ying Gai
Li, Chao
Westin, Erik
Li, Wei
Zhao, Rui
Generation of inducible pluripotent stem cell lines from Alzheimer’s disease patients with APOE e3/e3 genotype
title Generation of inducible pluripotent stem cell lines from Alzheimer’s disease patients with APOE e3/e3 genotype
title_full Generation of inducible pluripotent stem cell lines from Alzheimer’s disease patients with APOE e3/e3 genotype
title_fullStr Generation of inducible pluripotent stem cell lines from Alzheimer’s disease patients with APOE e3/e3 genotype
title_full_unstemmed Generation of inducible pluripotent stem cell lines from Alzheimer’s disease patients with APOE e3/e3 genotype
title_short Generation of inducible pluripotent stem cell lines from Alzheimer’s disease patients with APOE e3/e3 genotype
title_sort generation of inducible pluripotent stem cell lines from alzheimer’s disease patients with apoe e3/e3 genotype
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496340/
https://www.ncbi.nlm.nih.gov/pubmed/34392011
http://dx.doi.org/10.1016/j.scr.2021.102498
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