Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy

BACKGROUND: Hypoxia is a striking feature of most solid tumors and could be used to discriminate tumors from normoxic tissues. Therefore, the design of hypoxia-conditioned Chimeric Antigen Receptor (CAR) T cells is a promising strategy to reduce on-target off-tumor toxicity in adoptive cell therapy....

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Detalles Bibliográficos
Autores principales: He, Huan, Liao, Qibin, Zhao, Chen, Zhu, Cuisong, Feng, Meiqi, Liu, Zhuoqun, Jiang, Lang, Zhang, Linxia, Ding, Xiangqing, Yuan, Min, Zhang, Xiaoyan, Xu, Jianqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496395/
https://www.ncbi.nlm.nih.gov/pubmed/34615704
http://dx.doi.org/10.1136/jitc-2021-002755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496395/
https://www.ncbi.nlm.nih.gov/pubmed/34615704
http://dx.doi.org/10.1136/jitc-2021-002755

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