Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples

Mitochondrial dysfunction is an early, imminent event in neurodegenerative disorders including Parkinson disease (PD) and Alzheimer disease (AD). The enzymatic pair PINK1 and PRKN/Parkin recognize and transiently label damaged mitochondria with ubiquitin (Ub) phosphorylated at Ser65 (p-S65-Ub) as a...

Descripción completa

Detalles Bibliográficos
Autores principales: Watzlawik, Jens O., Hou, Xu, Fricova, Dominika, Ramnarine, Chloe, Barodia, Sandeep K., Gendron, Tania F., Heckman, Michael G., DeTure, Michael, Siuda, Joanna, Wszolek, Zbigniew K., Scherzer, Clemens R., Ross, Owen A., Bu, Guojun, Dickson, Dennis W., Goldberg, Matthew S., Fiesel, Fabienne C., Springer, Wolfdieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Toolbox
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496550/
https://www.ncbi.nlm.nih.gov/pubmed/33112198
http://dx.doi.org/10.1080/15548627.2020.1834712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496550/
https://www.ncbi.nlm.nih.gov/pubmed/33112198
http://dx.doi.org/10.1080/15548627.2020.1834712

Ejemplares similares