SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation

Accumulation of toxic protein assemblies and damaged mitochondria are key features of neurodegenerative diseases, which arise in large part from clearance defects in the Macroautophagy/autophagy-lysosome system. The autophagy cargo receptor SQSTM1/p62 plays a major role in the clearance of ubiquitin...

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Detalles Bibliográficos
Autores principales: Fang, Cenxiao, Woo, Jung-A A., Liu, Tian, Zhao, Xingyu, Cazzaro, Sara, Yan, Yan, Matlack, Jenet, Kee, Teresa, LePochat, Patrick, Kang, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496729/
https://www.ncbi.nlm.nih.gov/pubmed/33044112
http://dx.doi.org/10.1080/15548627.2020.1816663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496729/
https://www.ncbi.nlm.nih.gov/pubmed/33044112
http://dx.doi.org/10.1080/15548627.2020.1816663

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