Meta-analysis of transcriptomic data reveals clusters of consistently deregulated gene and disease ontologies in Down syndrome

Trisomy of human chromosome 21 (HSA21) causes Down syndrome (DS). The trisomy does not simply result in the upregulation of HSA21--encoded genes but also leads to a genome-wide transcriptomic deregulation, which affect differently each tissue and cell type as a result of epigenetic mechanisms and pr...

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Detalles Bibliográficos
Autores principales: De Toma, Ilario, Sierra, Cesar, Dierssen, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496798/
https://www.ncbi.nlm.nih.gov/pubmed/34570756
http://dx.doi.org/10.1371/journal.pcbi.1009317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496798/
https://www.ncbi.nlm.nih.gov/pubmed/34570756
http://dx.doi.org/10.1371/journal.pcbi.1009317

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