Cargando…

4-Coumaroyl-CoA ligases in the biosynthesis of the anti-diabetic metabolite montbretin A

BACKGROUND: Montbretins are rare specialized metabolites found in montbretia (Crocosmia x crocosmiiflora) corms. Montbretin A (MbA) is of particular interest as a novel therapeutic for type-2 diabetes and obesity. There is no scalable production system for this complex acylated flavonol glycoside. M...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sunstrum, Frederick G., Liu, Hannah L., Jancsik, Sharon, Madilao, Lufiani L., Bohlmann, Joerg, Irmisch, Sandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496819/ https://www.ncbi.nlm.nih.gov/pubmed/34618820 http://dx.doi.org/10.1371/journal.pone.0257478

Ejemplares similares

Biosynthesis of the anti‐diabetic metabolite montbretin A: glucosylation of the central intermediate mini‐MbA
por: Irmisch, Sandra, et al.
Publicado: (2019)

Biosynthesis of Sandalwood Oil: Santalum album CYP76F Cytochromes P450 Produce Santalols and Bergamotol
por: Diaz-Chavez, Maria L., et al.
Publicado: (2013)

Gymnosperm glandular trichomes: expanded dimensions of the conifer terpenoid defense system
por: Celedon, Jose M., et al.
Publicado: (2020)

A p-Coumaroyl-CoA Biosensor for Dynamic Regulation of Naringenin Biosynthesis in Saccharomyces cerevisiae
por: Liu, Dany, et al.
Publicado: (2022)

Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase
por: Tysoe, Christina R., et al.
Publicado: (2019)

Biomarkers and gene copy number variation for terpenoid traits associated with insect resistance in Sitka spruce: An integrated genomic, proteomic, and biochemical analysis of (+)-3-carene biosynthesis
por: Bohlmann, Joerg, et al.
Publicado: (2011)

Odorant cues linked to social immunity induce lateralized antenna stimulation in honey bees (Apis mellifera L.)
por: McAfee, Alison, et al.
Publicado: (2017)

The Fermentation Stress Response Protein Aaf1p/Yml081Wp Regulates Acetate Production in Saccharomyces cerevisiae
por: Walkey, Christopher J., et al.
Publicado: (2012)

In vivo function of Pgβglu-1 in the release of acetophenones in white spruce
por: Mageroy, Melissa H., et al.
Publicado: (2017)

Phenolic metabolism in the hornwort Anthoceros agrestis: 4-coumarate CoA ligase and 4-hydroxybenzoate CoA ligase
por: Wohl, Julia, et al.
Publicado: (2020)

High-throughput mapping of CoA metabolites by SAMDI-MS to optimize the cell-free biosynthesis of HMG-CoA
por: O’Kane, Patrick T., et al.
Publicado: (2019)

p-Coumaroylation of poplar lignins impacts lignin structure and improves wood saccharification
por: Lapierre, Catherine, et al.
Publicado: (2021)

Changes in cell walls lignification, feruloylation and p-coumaroylation throughout maize internode development
por: Zhang, Yu, et al.
Publicado: (2019)

p-Coumaroylation of lignin occurs outside of commelinid monocots in the eudicot genus Morus (mulberry)
por: Hellinger, Jan, et al.
Publicado: (2022)

Evolution of p‐coumaroylated lignin in eudicots provides new tools for cell wall engineering
por: Mottiar, Yaseen, et al.
Publicado: (2022)

Phenotypic variability in deficiency of the α subunit of succinate‐CoA ligase
por: Demirbas, Didem, et al.
Publicado: (2019)

Identification and suppression of the p-coumaroyl CoA:hydroxycinnamyl alcohol transferase in Zea mays L.
por: Marita, Jane M, et al.
Publicado: (2014)

Role of the p-Coumaroyl Moiety in the Antioxidant and Cytoprotective Effects of Flavonoid Glycosides: Comparison of Astragalin and Tiliroside
por: Li, Xican, et al.
Publicado: (2017)

Correction to: p-Coumaroylation of lignin occurs outside of commelinid monocots in the eudicot genus Morus (mulberry)
Publicado: (2022)

p-Coumaroyl-CoA:monolignol transferase (PMT) acts specifically in the lignin biosynthetic pathway in Brachypodium distachyon
por: Petrik, Deborah L, et al.
Publicado: (2014)

Biosynthesis of angelyl-CoA in Saccharomyces cerevisiae
por: Callari, Roberta, et al.
Publicado: (2018)

Coumaroyl Flavonol Glycosides and More in Marketed Green Teas: An Intrinsic Value beyond Much-Lauded Catechins
por: Candela, Lorenzo, et al.
Publicado: (2020)

Transcriptome mining, functional characterization, and phylogeny of a large terpene synthase gene family in spruce (Picea spp.)
por: Keeling, Christopher I, et al.
Publicado: (2011)

A death pheromone, oleic acid, triggers hygienic behavior in honey bees (Apis mellifera L.)
por: McAfee, Alison, et al.
Publicado: (2018)

4-Coumarate-CoA Ligase-Like Gene OsAAE3 Negatively Mediates the Rice Blast Resistance, Floret Development and Lignin Biosynthesis
por: Liu, Hao, et al.
Publicado: (2017)

Phytochemical Investigation of Myrcianthes cisplatensis: Structural Characterization of New p-Coumaroyl Alkylphloroglucinols and Antimicrobial Evaluation against Staphylococcus aureus
por: Guzzo, Francesca, et al.
Publicado: (2023)

ATP-dependent ligases in trypanothione biosynthesis – kinetics of catalysis and inhibition by phosphinic acid pseudopeptides
por: Oza, Sandra L, et al.
Publicado: (2008)

Genomic virulence features of Beauveria bassiana as a biocontrol agent for the mountain pine beetle population
por: Li, Janet X., et al.
Publicado: (2023)

A novel multidomain acyl-CoA carboxylase in Saccharopolyspora erythraea provides malonyl-CoA for de novo fatty acid biosynthesis
por: Livieri, Andrea L., et al.
Publicado: (2019)

Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme
por: Wang, Nan, et al.
Publicado: (2018)

Knockdown of p-Coumaroyl Shikimate/Quinate 3′-Hydroxylase Delays the Occurrence of Post-Harvest Physiological Deterioration in Cassava Storage Roots
por: Ma, Qiuxiang, et al.
Publicado: (2022)

Pantothenate and CoA biosynthesis in Apicomplexa and their promise as antiparasitic drug targets
por: de Vries, Laura E., et al.
Publicado: (2021)

Biosynthesis of Vanillin by Rational Design of Enoyl-CoA Hydratase/Lyase
por: Ye, Qi, et al.
Publicado: (2023)

Cloning and Functional Characterization of Two 4-Coumarate: CoA Ligase Genes from Selaginella moellendorffii
por: Liu, Xin-Yan, et al.
Publicado: (2018)

Overexpression of Acyl-CoA Ligase 4 (ACSL4) in Patients with Hepatocellular Carcinoma and its Prognosis
por: Sun, Xiao-Jie, et al.
Publicado: (2017)

The presence of benzene ring activating CoA ligases for aromatics degradation in the ANaerobic MEthanotrophic (ANME) archaea
por: Liu, Wei-Wei, et al.
Publicado: (2023)

Phosphorylation of Akt Mediates Anti-Inflammatory Activity of 1-p-Coumaroyl β-D-Glucoside Against Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells
por: Vo, Van Anh, et al.
Publicado: (2014)

Apigenin-7-O-β-D-(-6''-p-coumaroyl)-Glucopyranoside Treatment Elicits Neuroprotective Effect against Experimental Ischemic Stroke
por: Cai, Min, et al.
Publicado: (2016)

Identification of Dephospho-Coenzyme A (Dephospho-CoA) Kinase in Thermococcus kodakarensis and Elucidation of the Entire CoA Biosynthesis Pathway in Archaea
por: Shimosaka, Takahiro, et al.
Publicado: (2019)

Genetic basis and dual adaptive role of floral pigmentation in sunflowers
por: Todesco, Marco, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_72eck4uv0gm2ts30u1ome253i0