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Bone‐derived sclerostin and Wnt/β‐catenin signaling regulate PDGFRα(+) adipoprogenitor cell differentiation
The Wnt signaling antagonist, sclerostin, is a potent suppressor of bone acquisition that also mediates endocrine communication between bone and adipose. As a result, Sost(−/−) mice exhibit dramatic increases in bone formation but marked decreases in visceral and subcutaneous adipose that are second...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496915/ https://www.ncbi.nlm.nih.gov/pubmed/34606641 http://dx.doi.org/10.1096/fj.202100691R |