Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness. Intriguingly, stem/progenitor cells maintaining repressed mitochondri...

Descripción completa

Detalles Bibliográficos
Autores principales: Spurlock, Brian, Parker, Danitra, Basu, Malay Kumar, Hjelmeland, Anita, GC, Sajina, Liu, Shanrun, Siegal, Gene P, Gunter, Alan, Moran, Aida, Mitra, Kasturi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497058/
https://www.ncbi.nlm.nih.gov/pubmed/34545812
http://dx.doi.org/10.7554/eLife.68394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497058/
https://www.ncbi.nlm.nih.gov/pubmed/34545812
http://dx.doi.org/10.7554/eLife.68394

Ejemplares similares