Cargando…

M6A methylation of DEGS2, a key ceramide-synthesizing enzyme, is involved in colorectal cancer progression through ceramide synthesis

N6-methyladenosine (m6A) is the most prevalent RNA epigenetic regulator in cancer. However, the understanding of m6A modification on lipid metabolism regulation in colorectal cancer (CRC) is very limited. Here, we observed that human CRCs exhibited increased m6A mRNA methylation mediated by dysregul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Wei, Zhang, Cuiyu, Feng, Panpan, Li, Mingying, Wang, Xia, Xia, Yuan, Chen, Dawei, Li, Jingxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497269/ https://www.ncbi.nlm.nih.gov/pubmed/34363020 http://dx.doi.org/10.1038/s41388-021-01987-z

Ejemplares similares

Ceramide and ceramide 1-phosphate in health and disease
por: Arana, Lide, et al.
Publicado: (2010)

Intracellular trafficking of ceramide by ceramide transfer protein
por: Hanada, Kentaro
Publicado: (2010)

Mechanisms involved in cellular ceramide homeostasis
por: Hussain, M Mahmood, et al.
Publicado: (2012)

Involvement of Ceramide Metabolism in Cerebral Ischemia
por: Ouro, Alberto, et al.
Publicado: (2022)

Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis
por: Igarashi, Tami, et al.
Publicado: (2023)

Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis
por: Kim, Jiyoon L., et al.
Publicado: (2022)

Exogenous Ceramide Serves as a Precursor to Endogenous Ceramide Synthesis and as a Modulator of Keratinocyte Differentiation
por: Shin, Kyong-Oh, et al.
Publicado: (2022)

Relationship between hepatic and mitochondrial ceramides: a novel in vivo method to track ceramide synthesis
por: Mucinski, Justine M., et al.
Publicado: (2023)

Convergent evolution of bacterial ceramide synthesis
por: Stankeviciute, Gabriele, et al.
Publicado: (2022)

Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody
por: Jiang, Xue, et al.
Publicado: (2019)

Ceramide in the prostate
por: Dent, Paul
Publicado: (2013)

Antibacterial activity of ceramide and ceramide analogs against pathogenic Neisseria
por: Becam, Jérôme, et al.
Publicado: (2017)

The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by Adipokines
por: Field, Bianca C., et al.
Publicado: (2020)

Ceramides and Ceramide Scores: Clinical Applications for Cardiometabolic Risk Stratification
por: Hilvo, Mika, et al.
Publicado: (2020)

Ceramides in Adipose Tissue
por: Li, Ying, et al.
Publicado: (2020)

Ceramide in cerebrovascular diseases
por: Yuan, Huiqi, et al.
Publicado: (2023)

Ceramide is involved in alcohol-induced neural proliferation
por: Wang, Zhixin, et al.
Publicado: (2013)

Ceramide Metabolism Enzymes—Therapeutic Targets against Cancer
por: Gomez-Larrauri, Ana, et al.
Publicado: (2021)

Implication of Ceramide, Ceramide 1-Phosphate and Sphingosine 1-Phosphate in Tumorigenesis
por: Gangoiti, Patricia, et al.
Publicado: (2008)

Targeting Ceramide Synthesis to Reverse Insulin Resistance
por: Schmitz-Peiffer, Carsten
Publicado: (2010)

Insulin Increases Ceramide Synthesis in Skeletal Muscle
por: Hansen, M. E., et al.
Publicado: (2014)

Synthesis and biological activity of α-galactosyl ceramide KRN7000 and galactosyl (α1→2) galactosyl ceramide
por: Veerapen, Natacha, et al.
Publicado: (2009)

Chemotherapy with ceramide in TNBC
por: Legembre, Patrick, et al.
Publicado: (2015)

Ceramide in Stress Response
por: Nikolova-Karakashian, Mariana N., et al.
Publicado: (2010)

New role for ceramide in hypoxia and insulin resistance
por: Xia, Qing-Song, et al.
Publicado: (2020)

Novel Role for Ceramides in Colorectal Cancer Liver Metastases
por: Tian, Lucy Lu, et al.
Publicado: (2023)

Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine ceramides
por: Ota, Ai, et al.
Publicado: (2023)

Synthesis and biological activity of α-l-fucosyl ceramides, analogues of the potent agonist, α-d-galactosyl ceramide KRN7000
por: Veerapen, Natacha, et al.
Publicado: (2010)

Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma
por: Wang, Zheng, et al.
Publicado: (2017)

Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth
por: Oh, Jee Hye, et al.
Publicado: (2019)

Ceramide and Ischemia/Reperfusion Injury
por: He, Xingxuan, et al.
Publicado: (2018)

Strong Heart, Low Ceramides
por: Holland, William L., et al.
Publicado: (2018)

Implication of Ceramide Kinase in Adipogenesis
por: Ordoñez, Marta, et al.
Publicado: (2017)

Ceramide and Regulation of Vascular Tone
por: Cogolludo, Angel, et al.
Publicado: (2019)

The Role of Ceramides in Insulin Resistance
por: Sokolowska, Emilia, et al.
Publicado: (2019)

Mechanisms of Nonvesicular Ceramide Transport
por: Clausmeyer, Lena, et al.
Publicado: (2023)

Ceramides and Cell Signaling Molecules in Psoriatic Epidermis: Reduced Levels of Ceramides, PKC-α, and JNK
por: Lew, Bark-Lynn, et al.
Publicado: (2006)

Oxidized Phospholipids Induce Ceramide Accumulation in RAW 264.7 Macrophages: Role of Ceramide Synthases
por: Halasiddappa, Lingaraju M., et al.
Publicado: (2013)

Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death
por: Schmidt, Steffen, et al.
Publicado: (2022)

Emerging Roles of Ceramide in Cardiovascular Diseases
por: Shu, Hongyang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2go0jur3k59qff8gb1e2i4rqic