Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage

The progression of osteoarthritis (OA) is associated with inflammation triggered by the enzymatic degradation of extracellular matrix in injured cartilage. Here, we show that a locally injected depot of nanoparticles functionalized with an antibody targeting collagen type-II and carrying small inter...

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Detalles Bibliográficos
Autores principales: Bedingfield, Sean K., Colazo, Juan M., Yu, Fang, Liu, Danielle D., Jackson, Meredith A., Himmel, Lauren E., Cho, Hongsik, Crofford, Leslie J., Hasty, Karen A., Duvall, Craig L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497446/
https://www.ncbi.nlm.nih.gov/pubmed/34413494
http://dx.doi.org/10.1038/s41551-021-00780-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497446/
https://www.ncbi.nlm.nih.gov/pubmed/34413494
http://dx.doi.org/10.1038/s41551-021-00780-3

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