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Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage
The progression of osteoarthritis (OA) is associated with inflammation triggered by the enzymatic degradation of extracellular matrix in injured cartilage. Here, we show that a locally injected depot of nanoparticles functionalized with an antibody targeting collagen type-II and carrying small inter...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497446/ https://www.ncbi.nlm.nih.gov/pubmed/34413494 http://dx.doi.org/10.1038/s41551-021-00780-3 |