Multi-omics driven predictions of response to acute phase combination antidepressant therapy: a machine learning approach with cross-trial replication

Combination antidepressant pharmacotherapies are frequently used to treat major depressive disorder (MDD). However, there is no evidence that machine learning approaches combining multi-omics measures (e.g., genomics and plasma metabolomics) can achieve clinically meaningful predictions of outcomes...

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Detalles Bibliográficos
Autores principales: Joyce, Jeremiah B., Grant, Caroline W., Liu, Duan, MahmoudianDehkordi, Siamak, Kaddurah-Daouk, Rima, Skime, Michelle, Biernacka, Joanna, Frye, Mark A., Mayes, Taryn, Carmody, Thomas, Croarkin, Paul E., Wang, Liewei, Weinshilboum, Richard, Bobo, William V., Trivedi, Madhukar H., Athreya, Arjun P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497535/
https://www.ncbi.nlm.nih.gov/pubmed/34620827
http://dx.doi.org/10.1038/s41398-021-01632-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497535/
https://www.ncbi.nlm.nih.gov/pubmed/34620827
http://dx.doi.org/10.1038/s41398-021-01632-z

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