Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors

Phospholipase D3 (PLD3) and PLD4 polymorphisms have been associated with several important inflammatory diseases. Here, we show that PLD3 and PLD4 digest ssRNA in addition to ssDNA as reported previously. Moreover, Pld3(−/−)Pld4(−/−) mice accumulate small ssRNAs and develop spontaneous fatal hemopha...

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Detalles Bibliográficos
Autores principales: Gavin, Amanda L., Huang, Deli, Blane, Tanya R., Thinnes, Therese C., Murakami, Yusuke, Fukui, Ryutaro, Miyake, Kensuke, Nemazee, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497607/
https://www.ncbi.nlm.nih.gov/pubmed/34620855
http://dx.doi.org/10.1038/s41467-021-26150-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497607/
https://www.ncbi.nlm.nih.gov/pubmed/34620855
http://dx.doi.org/10.1038/s41467-021-26150-w

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