Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents

Pathogenic fungi exhibit a heavy burden on medical care and new therapies are needed. Here, we develop the fungal specific enzyme sterylglucosidase 1 (Sgl1) as a therapeutic target. Sgl1 converts the immunomodulatory glycolipid ergosterol 3β-D-glucoside to ergosterol and glucose. Previously, we foun...

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Detalles Bibliográficos
Autores principales: Pereira de Sa, Nivea, Taouil, Adam, Kim, Jinwoo, Clement, Timothy, Hoffmann, Reece M., Burke, John E., Rizzo, Robert C., Ojima, Iwao, Del Poeta, Maurizio, Airola, Michael V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497620/
https://www.ncbi.nlm.nih.gov/pubmed/34620873
http://dx.doi.org/10.1038/s41467-021-26163-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497620/
https://www.ncbi.nlm.nih.gov/pubmed/34620873
http://dx.doi.org/10.1038/s41467-021-26163-5

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