In silico Identification of Disrupted Myocardial Calcium Homeostasis as Proarrhythmic Trigger in Arrhythmogenic Cardiomyopathy

Background: Patients with arrhythmogenic cardiomyopathy may suffer from lethal ventricular arrhythmias. Arrhythmogenic cardiomyopathy is predominantly triggered by mutations in plakophilin-2, a key component of cell-to-cell adhesion and calcium cycling regulation in cardiomyocytes. Calcium dysregula...

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Detalles Bibliográficos
Autores principales: Lyon, Aurore, van Opbergen, Chantal J. M., Delmar, Mario, Heijman, Jordi, van Veen, Toon A. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497808/
https://www.ncbi.nlm.nih.gov/pubmed/34630150
http://dx.doi.org/10.3389/fphys.2021.732573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497808/
https://www.ncbi.nlm.nih.gov/pubmed/34630150
http://dx.doi.org/10.3389/fphys.2021.732573

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