Topological analyses of the L-lysine exporter LysO reveal a critical role for a conserved pair of intramembrane solvent-exposed acidic residues

LysO, a prototypical member of the LysO family, mediates export of L-lysine (Lys) and resistance to the toxic Lys antimetabolite, L-thialysine (Thl) in Escherichia coli. Here, we have addressed unknown aspects of LysO function pertaining to its membrane topology and the mechanism by which it mediate...

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Detalles Bibliográficos
Autores principales: Dubey, Swati, Majumder, Puja, Penmatsa, Aravind, Sardesai, Abhijit A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498466/
https://www.ncbi.nlm.nih.gov/pubmed/34487760
http://dx.doi.org/10.1016/j.jbc.2021.101168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498466/
https://www.ncbi.nlm.nih.gov/pubmed/34487760
http://dx.doi.org/10.1016/j.jbc.2021.101168

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