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RetS inhibits Pseudomonas aeruginosa biofilm formation by disrupting the canonical histidine kinase dimerization interface of GacS

Bacterial signaling histidine kinases (HKs) have long been postulated to function exclusively through linear signal transduction chains. However, several HKs have recently been shown to form complex multikinase networks (MKNs). The most prominent MKN, involving the enzymes RetS and GacS, controls th...

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Detalles Bibliográficos
Autores principales: Ryan Kaler, Kylie M., Nix, Jay C., Schubot, Florian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498467/
https://www.ncbi.nlm.nih.gov/pubmed/34529974
http://dx.doi.org/10.1016/j.jbc.2021.101193