TGF-β/activin signaling promotes CDK7 inhibitor resistance in triple-negative breast cancer cells through upregulation of multidrug transporters

Cyclin-dependent kinase 7 (CDK7) is a master regulatory kinase that drives cell cycle progression and stimulates expression of oncogenes in a myriad of cancers. Inhibitors of CDK7 (CDK7i) are currently in clinical trials; however, as with many cancer therapies, patients will most likely experience r...

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Detalles Bibliográficos
Autores principales: Webb, Bryan M., Bryson, Benjamin L., Williams-Medina, Eduardo, Bobbitt, Jessica R., Seachrist, Darcie D., Anstine, Lindsey J., Keri, Ruth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498470/
https://www.ncbi.nlm.nih.gov/pubmed/34481843
http://dx.doi.org/10.1016/j.jbc.2021.101162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498470/
https://www.ncbi.nlm.nih.gov/pubmed/34481843
http://dx.doi.org/10.1016/j.jbc.2021.101162

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