Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis In Vivo and Baseline Signaling Profile Associates With Treatment Response

OBJECTIVE: Current knowledge on the actions of tofacitinib on cytokine signaling pathways in rheumatoid arthritis (RA) is based on in vitro studies. Our study is the first to examine the effects of tofacitinib treatment on Janus kinase (JAK) - signal transducer and activator of transcription (STAT)...

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Detalles Bibliográficos
Autores principales: Palmroth, Maaria, Kuuliala, Krista, Peltomaa, Ritva, Virtanen, Anniina, Kuuliala, Antti, Kurttila, Antti, Kinnunen, Anna, Leirisalo-Repo, Marjatta, Silvennoinen, Olli, Isomäki, Pia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498592/
https://www.ncbi.nlm.nih.gov/pubmed/34630419
http://dx.doi.org/10.3389/fimmu.2021.738481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498592/
https://www.ncbi.nlm.nih.gov/pubmed/34630419
http://dx.doi.org/10.3389/fimmu.2021.738481

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