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Synthesis of Indofulvin Pseudo‐Natural Products Yields a New Autophagy Inhibitor Chemotype

Chemical and biological limitations in bioactive compound design based on natural product (NP) structure can be overcome by the combination of NP‐derived fragments in unprecedented arrangements to afford “pseudo‐natural products” (pseudo‐NPs). A new pseudo‐NP design principle is described, i.e., the...

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Detalles Bibliográficos
Autores principales: Burhop, Annina, Bag, Sukdev, Grigalunas, Michael, Woitalla, Sophie, Bodenbinder, Pia, Brieger, Lukas, Strohmann, Carsten, Pahl, Axel, Sievers, Sonja, Waldmann, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498912/
https://www.ncbi.nlm.nih.gov/pubmed/34346568
http://dx.doi.org/10.1002/advs.202102042