Scaffold Hybridization Strategy Leads to the Discovery of Dopamine D(3) Receptor-Selective or Multitarget Bitopic Ligands Potentially Useful for Central Nervous System Disorders

[Image: see text] In the search for novel bitopic compounds targeting the dopamine D(3) receptor (D(3)R), the N-(2,3-dichlorophenyl)piperazine nucleus (primary pharmacophore) has been linked to the 6,6- or 5,5-diphenyl-1,4-dioxane-2-carboxamide or the 1,4-benzodioxane-2-carboxamide scaffold (seconda...

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Detalles Bibliográficos
Autores principales: Bonifazi, Alessandro, Newman, Amy H., Keck, Thomas M., Gervasoni, Silvia, Vistoli, Giulio, Del Bello, Fabio, Giorgioni, Gianfabio, Pavletić, Pegi, Quaglia, Wilma, Piergentili, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498988/
https://www.ncbi.nlm.nih.gov/pubmed/34529404
http://dx.doi.org/10.1021/acschemneuro.1c00368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498988/
https://www.ncbi.nlm.nih.gov/pubmed/34529404
http://dx.doi.org/10.1021/acschemneuro.1c00368

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