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The [4Fe4S] Cluster of Yeast DNA Polymerase ε Is Redox Active and Can Undergo DNA-Mediated Signaling

[Image: see text] Many DNA replication and DNA repair enzymes have been found to carry [4Fe4S] clusters. The major leading strand polymerase, DNA polymerase ε (Pol ε) from Saccharomyces cerevisiae, was recently reported to have a [4Fe4S] cluster located within the catalytic domain of the largest sub...

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Detalles Bibliográficos
Autores principales: Pinto, Miguel N., ter Beek, Josy, Ekanger, Levi A., Johansson, Erik, Barton, Jacqueline K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499023/
https://www.ncbi.nlm.nih.gov/pubmed/34559527
http://dx.doi.org/10.1021/jacs.1c07150