A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility

[Image: see text] Triazole linkages (TLs) are mimics of the phosphodiester bond in oligonucleotides with applications in synthetic biology and biotechnology. Here we report the RuAAC-catalyzed synthesis of a novel 1,5-disubstituted triazole (TL2) dinucleoside phosphoramidite as well as its incorpora...

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Detalles Bibliográficos
Autores principales: Epple, Sven, Modi, Aman, Baker, Ysobel R., Wȩgrzyn, Ewa, Traoré, Diallo, Wanat, Przemyslaw, Tyburn, Agnes E. S., Shivalingam, Arun, Taemaitree, Lapatrada, El-Sagheer, Afaf H., Brown, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499026/
https://www.ncbi.nlm.nih.gov/pubmed/34546729
http://dx.doi.org/10.1021/jacs.1c08057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499026/
https://www.ncbi.nlm.nih.gov/pubmed/34546729
http://dx.doi.org/10.1021/jacs.1c08057

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