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A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility
[Image: see text] Triazole linkages (TLs) are mimics of the phosphodiester bond in oligonucleotides with applications in synthetic biology and biotechnology. Here we report the RuAAC-catalyzed synthesis of a novel 1,5-disubstituted triazole (TL2) dinucleoside phosphoramidite as well as its incorpora...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499026/ https://www.ncbi.nlm.nih.gov/pubmed/34546729 http://dx.doi.org/10.1021/jacs.1c08057 |