Longitudinal clonal tracking in humanized mice reveals sustained polyclonal repopulation of gene-modified human-HSPC despite vector integration bias

BACKGROUND: Current understanding of hematopoiesis is largely derived from mouse models that are physiologically distant from humans. Humanized mice provide the most physiologically relevant small animal model to study human diseases, most notably preclinical gene therapy studies. However, the clona...

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Detalles Bibliográficos
Autores principales: Suryawanshi, Gajendra W., Arokium, Hubert, Kim, Sanggu, Khamaikawin, Wannisa, Lin, Samantha, Shimizu, Saki, Chupradit, Koollawat, Lee, YooJin, Xie, Yiming, Guan, Xin, Suryawanshi, Vasantika, Presson, Angela P., An, Dong-Sung, Chen, Irvin S. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499514/
https://www.ncbi.nlm.nih.gov/pubmed/34620229
http://dx.doi.org/10.1186/s13287-021-02601-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499514/
https://www.ncbi.nlm.nih.gov/pubmed/34620229
http://dx.doi.org/10.1186/s13287-021-02601-5

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