Cargando…

Reciprocal deregulation of NKX3.1 and AURKA axis in castration-resistant prostate cancer and NEPC models

BACKGROUND: NKX3.1, a prostate-specific tumor suppressor, is either genomically lost or its protein levels are severely downregulated, which are invariably associated with poor prognosis in prostate cancer (PCa). Nevertheless, a clear disconnect exists between its mRNA and protein levels, indicating...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sooreshjani, Moloud Aflaki, Kamra, Mohini, Zoubeidi, Amina, Shah, Kavita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499580/ https://www.ncbi.nlm.nih.gov/pubmed/34625072 http://dx.doi.org/10.1186/s12929-021-00765-z

Ejemplares similares

LIMK2-NKX3.1 Engagement Promotes Castration-Resistant Prostate Cancer
por: Sooreshjani, Moloud A., et al.
Publicado: (2021)

Molecular Interplay between AURKA and SPOP Dictates CRPC Pathogenesis via Androgen Receptor
por: Nikhil, Kumar, et al.
Publicado: (2020)

The central role of Sphingosine kinase 1 in the development of neuroendocrine prostate cancer (NEPC): A new targeted therapy of NEPC
por: Lee, Cheng‐Fan, et al.
Publicado: (2022)

Phosphorylation-dependent regulation of SPOP by LIMK2 promotes castration-resistant prostate cancer
por: Nikhil, Kumar, et al.
Publicado: (2020)

Proteomic analysis of RAW macrophages treated with cGAMP or c-di-GMP reveals differentially activated cellular pathways
por: Sooreshjani, Moloud Aflaki, et al.
Publicado: (2018)

The expression of AURKA is androgen regulated in castration-resistant prostate cancer
por: Kivinummi, Kati, et al.
Publicado: (2017)

NKL Homeobox Genes NKX2-3 and NKX2-4 Deregulate Megakaryocytic-Erythroid Cell Differentiation in AML
por: Nagel, Stefan, et al.
Publicado: (2021)

The Role of Nkx3.1 in Cancers and Stemness
por: Antao, Ainsley Mike, et al.
Publicado: (2021)

Dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations potently inhibits acute myeloid leukemia cell lines
por: Dayal, Neetu, et al.
Publicado: (2018)

Nkx3.1 controls the DNA repair response in the mouse prostate
por: Zhang, Hailan, et al.
Publicado: (2015)

Cooperation of loss of NKX3.1 and inflammation in prostate cancer initiation
por: Le Magnen, Clémentine, et al.
Publicado: (2018)

CCNB1 and AURKA are critical genes for prostate cancer progression and castration-resistant prostate cancer resistant to vinblastine
por: Chen, Xi, et al.
Publicado: (2022)

Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells
por: Yang, Yan, et al.
Publicado: (2020)

Inhibition of the HER2-YB1-AR axis with Lapatinib synergistically enhances Enzalutamide anti-tumor efficacy in castration resistant prostate cancer
por: Shiota, Masaki, et al.
Publicado: (2015)

AURKA inhibition mimics BRCAness
por: Hirst, Jeff, et al.
Publicado: (2017)

PUF60/AURKA Axis Contributes to Tumor Progression and Malignant Phenotypes in Bladder Cancer
por: Long, Qian, et al.
Publicado: (2020)

The loss of NKX3.1 expression in testicular – and prostate – cancers is not caused by promoter hypermethylation
por: Lind, Guro E, et al.
Publicado: (2005)

Antioxidant Treatment Promotes Prostate Epithelial Proliferation in Nkx3.1 Mutant Mice
por: Martinez, Erin E., et al.
Publicado: (2012)

miR-378b Promotes Differentiation of Keratinocytes through NKX3.1
por: Wang, Xi-liang, et al.
Publicado: (2015)

NKX3.1 Expression Contributes to Epithelial–Mesenchymal Transition of Prostate Cancer Cells
por: Saydullaeva, Iroda, et al.
Publicado: (2023)

STIL/AURKA axis promotes cell proliferation by influencing primary cilia formation in bladder cancer
por: Li, Jingxian, et al.
Publicado: (2023)

Concurrent Down-Regulation of PTEN and NKX3.1 Expression in Iranian Patients with Prostate Cancer
por: Nodouzi, Vahideh, et al.
Publicado: (2015)

Integrated pan‐cancer of AURKA expression and drug sensitivity analysis reveals increased expression of AURKA is responsible for drug resistance
por: Miralaei, Noushin, et al.
Publicado: (2021)

Loss-of-Nkx3.1 Leads to Activation of Discrete Downstream Target Genes during Prostate Tumorigenesis
por: Song, Haengseok, et al.
Publicado: (2009)

The Homeodomain Transcription Factor NKX3.1 Modulates Bladder Outlet Obstruction Induced Fibrosis in Mice
por: Patel, Mehul S., et al.
Publicado: (2019)

Local and systemic modulation of the PD-L1 pathway is a novel mechanism of Enzalutamide resistance in castration-resistant prostate cancer
por: Bishop, Jennifer, et al.
Publicado: (2014)

Bioinformatics and experimental validation of an AURKA/TPX2 axis as a potential target in esophageal squamous cell carcinoma
por: Du, Ruijuan, et al.
Publicado: (2023)

Association between the functional polymorphism Ile31Phe in the AURKA gene and susceptibility of hepatocellular carcinoma in chronic hepatitis B virus carriers
por: Bao, Zhiyu, et al.
Publicado: (2017)

MYC Overexpression Induces Prostatic Intraepithelial Neoplasia and Loss of Nkx3.1 in Mouse Luminal Epithelial Cells
por: Iwata, Tsuyoshi, et al.
Publicado: (2010)

Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer
por: Thangapazham, Rajesh, et al.
Publicado: (2014)

Distinct DNA methylation patterns associated with treatment resistance in metastatic castration resistant prostate cancer
por: Peter, Madonna R., et al.
Publicado: (2021)

Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer
por: Zimmer, Brenna M., et al.
Publicado: (2021)

Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation
por: Yang, Chih-Cheng, et al.
Publicado: (2014)

NKX2-8/PTHrP Axis-Mediated Osteoclastogenesis and Bone Metastasis in Breast Cancer
por: Abudourousuli, Ainiwaerjiang, et al.
Publicado: (2022)

Dual BRD4 and AURKA Inhibition Is Synergistic against MYCN-Amplified and Nonamplified Neuroblastoma()
por: Felgenhauer, Joshua, et al.
Publicado: (2018)

Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation
por: Lelong, Emeline I J, et al.
Publicado: (2022)

A single nucleotide polymorphism in codon F31I and V57I of the AURKA gene in invasive ductal breast carcinoma in Middle East
por: Golmohammadi, Rahim, et al.
Publicado: (2017)

Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells
por: Wu, Changjie, et al.
Publicado: (2018)

Targeting megakaryocytic induced fibrosis by AURKA inhibition in the myeloproliferative neoplasms
por: Wen, Qiang Jeremy, et al.
Publicado: (2015)

Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma
por: Wang, Bin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_50leu0nc2sp47vh57gpbuqiqp7