Novel monkey mAbs induced by a therapeutic vaccine targeting the hepatitis B surface antigen effectively suppress hepatitis B virus in mice

BACKGROUND: We have previously obtained a mouse anti-hepatitis B surface antigen (HBsAg) antibody E6F6 with long-lasting serum HBsAg clearance effects. The E6F6 epitope-based protein CR-T3-SEQ13 (HBsAg aa 113-135) vaccination therapy in cynomolgus monkeys induced long-term polyclonal antibodies-medi...

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Detalles Bibliográficos
Autores principales: Chen, Yuanzhi, Xiang, Xinchu, Qi, Ruoyao, Wang, Yiwen, Huang, Yang, You, Min, Xian, Yangfei, Wu, Yangtao, Fu, Rao, Kang, Ciming, Tang, Jixian, Yu, Hai, Zhang, Tianying, Yuan, Quan, Luo, Wenxin, Xia, Ningshao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499627/
https://www.ncbi.nlm.nih.gov/pubmed/34646979
http://dx.doi.org/10.1093/abt/tbab020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499627/
https://www.ncbi.nlm.nih.gov/pubmed/34646979
http://dx.doi.org/10.1093/abt/tbab020

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