Cargando…

Novel monkey mAbs induced by a therapeutic vaccine targeting the hepatitis B surface antigen effectively suppress hepatitis B virus in mice

BACKGROUND: We have previously obtained a mouse anti-hepatitis B surface antigen (HBsAg) antibody E6F6 with long-lasting serum HBsAg clearance effects. The E6F6 epitope-based protein CR-T3-SEQ13 (HBsAg aa 113-135) vaccination therapy in cynomolgus monkeys induced long-term polyclonal antibodies-medi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yuanzhi, Xiang, Xinchu, Qi, Ruoyao, Wang, Yiwen, Huang, Yang, You, Min, Xian, Yangfei, Wu, Yangtao, Fu, Rao, Kang, Ciming, Tang, Jixian, Yu, Hai, Zhang, Tianying, Yuan, Quan, Luo, Wenxin, Xia, Ningshao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499627/ https://www.ncbi.nlm.nih.gov/pubmed/34646979 http://dx.doi.org/10.1093/abt/tbab020

Ejemplares similares

A novel therapeutic anti-HBV antibody with increased binding to human FcRn improves in vivo PK in mice and monkeys
por: Kang, Ciming, et al.
Publicado: (2017)

Detection and analysis of tupaia hepatocytes via mAbs against tupaia serum albumin
por: Liu, Xuan, et al.
Publicado: (2015)

SEPPA-mAb: spatial epitope prediction of protein antigens for mAbs
por: Qiu, Tianyi, et al.
Publicado: (2023)

Combination therapy of therapeutic antibody and vaccine or entecavir in HBV carrier mice
por: Qi, Ruoyao, et al.
Publicado: (2023)

Hepatitis B Core Antibody Level: A Surrogate Marker for Host Antiviral Immunity in Chronic Hepatitis B Virus Infections
por: Shi, Yang, et al.
Publicado: (2023)

Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs
por: Fusco, Marnie L., et al.
Publicado: (2015)

The Different Colors of mAbs in Solution
por: Ambrogelly, Alexandre
Publicado: (2021)

Correction: Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs
por: Fusco, Marnie L., et al.
Publicado: (2015)

Serum hepatitis B virus RNA detectability, composition and clinical significance in patients with ab initio hepatitis B e antigen negative chronic hepatitis B
por: Laras, Andreas, et al.
Publicado: (2022)

Complement system in Anti-CD20 mAb therapy for cancer: A mini-review
por: Gao, Yiwen
Publicado: (2023)

An HBV-tolerant immunocompetent model that effectively simulates chronic hepatitis B virus infection in mice
por: Yuan, Lunzhi, et al.
Publicado: (2016)

Novel human partner cell line for immortalisation of rare antigen-specific B cells in mAb development
por: Kaseko, Galina, et al.
Publicado: (2011)

Cellular tools for biosimilar mAb analysis
por: Lindemann, Carsten, et al.
Publicado: (2013)

Evolving trends in mAb production processes
por: Shukla, Abhinav A., et al.
Publicado: (2017)

State of the art in anti-cancer mAbs
por: Chiavenna, S. M., et al.
Publicado: (2017)

Development of functional antibodies against influenza B virus by activation-induced cytidine deaminase in hybridoma cells
por: Chen, Yuanzhi, et al.
Publicado: (2022)

Stability enhancement in a mAb and Fab coformulation
por: Zhang, Hongyu, et al.
Publicado: (2020)

Pan-sarbecovirus mAb protects from variants
por: Flemming, Alexandra
Publicado: (2021)

A mAb for the detection of the antiretroviral drug emtricitabine
por: Youngpairoj, Ae S., et al.
Publicado: (2022)

Correlations between serum hepatitis B core-related antigen and hepatitis B surface antigen in patients with hepatitis B cirrhosis and a hepatitis B virus-DNA-negative status: a retrospective study
por: Xu, Baiguo, et al.
Publicado: (2022)

ER stress regulating protein phosphatase 2A-B56γ, targeted by hepatitis B virus X protein, induces cell cycle arrest and apoptosis of hepatocytes
por: He, Chengyong, et al.
Publicado: (2018)

The Shortage of M.A.B. Nurses
Publicado: (1918)

Nursing under the M.A.B.
Publicado: (1920)

Preparation and functional evaluation of monoclonal antibodies targeting Hepatitis B Virus Polymerase
por: Hu, Song, et al.
Publicado: (2021)

Structural Features of a Conformation-dependent Antigen Epitope on ORFV-B2L Recognized by the 2E4 mAb
por: Yu, Yongzhong, et al.
Publicado: (2019)

Serum hepatitis B core antibody as a biomarker of hepatic inflammation in chronic hepatitis B patients with normal alanine aminotransferase
por: Zhou, Jiyuan, et al.
Publicado: (2017)

Novel strategy for a high-yielding mAb-producing CHO strain (overexpression of non-coding RNA enhanced proliferation and improved mAb yield)
por: Tabuchi, Hisahiro
Publicado: (2013)

Correlation Between Quantitative Hepatitis B Surface Antigen and Hepatitis B Virus Deoxyribonucleic Acid Levels in Hepatitis B e Antigen-Positive and Hepatitis B e Antigen-Negative Chronic Hepatitis B Patients
por: Nirmala, Viva Finhar Insani, et al.
Publicado: (2023)

Hepatitis B Core-Related Antigen and New Therapies for Hepatitis B
por: Watanabe, Takehisa, et al.
Publicado: (2021)

Developmental changes in heparan sulfate expression: in situ detection with mAbs
Publicado: (1992)

Direct analysis of mAb aggregates in mammalian cell culture supernatant
por: Paul, Albert J, et al.
Publicado: (2014)

Conservancy of mAb Epitopes in Ebolavirus Glycoproteins of Previous and 2014 Outbreaks
por: Ponomarenko, Julia, et al.
Publicado: (2014)

Self-Interaction Chromatography of mAbs: Accurate Measurement of Dead Volumes
por: Hedberg, S. H. M., et al.
Publicado: (2015)

Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma
por: Kroesen, Michiel, et al.
Publicado: (2016)

Germinality does not necessarily define mAb expression and thermal stability
por: Schwaigerlehner, Linda, et al.
Publicado: (2019)

The Role of Complement in the Mechanism of Action of Therapeutic Anti-Cancer mAbs
por: Golay, Josée, et al.
Publicado: (2020)

Hepatitis B virus pre-genomic RNA and hepatitis B core-related antigen reductions at week 4 predict favourable hepatitis B surface antigen response upon long-term nucleos(t)ide analogue in chronic hepatitis B
por: Mak, Lung-Yi, et al.
Publicado: (2023)

Suppression of Rituximab-resistant B-cell lymphoma with a novel multi-component anti-CD20 mAb nanocluster
por: Li, Huafei, et al.
Publicado: (2015)

Development of Lentiviral Vectors Pseudotyped With Influenza B Hemagglutinins: Application in Vaccine Immunogenicity, mAb Potency, and Sero-Surveillance Studies
por: Ferrara, Francesca, et al.
Publicado: (2021)

A human monoclonal antibody against HPV16 recognizes an immunodominant and neutralizing epitope partially overlapping with that of H16.V5
por: Xia, Lin, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_22cmtepljd5ahfrev3qlt7313e