Cargando…

Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors

The mitochondrial unfolded protein response (mitoUPR) is an evolutionarily conserved pathway that responds to mitochondria insults through transcriptional changes, mediated by the transcription factor ATFS-1/ATF-5, which acts to restore mitochondrial homeostasis. In this work, we characterized the r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Soo, Sonja K, Traa, Annika, Rudich, Paige D, Mistry, Meeta, Van Raamsdonk, Jeremy M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500221/ https://www.ncbi.nlm.nih.gov/pubmed/34583931 http://dx.doi.org/10.26508/lsa.202101182

Ejemplares similares

Genetic basis of enhanced stress resistance in long‐lived mutants highlights key role of innate immunity in determining longevity
por: Soo, Sonja K., et al.
Publicado: (2022)

Targeting Mitochondrial Network Disorganization is Protective in C. elegans Models of Huntington’s Disease
por: Machiela, Emily, et al.
Publicado: (2021)

Identification of Novel Therapeutic Targets for Polyglutamine Diseases That Target Mitochondrial Fragmentation
por: Traa, Annika, et al.
Publicado: (2021)

Mild mitochondrial impairment enhances innate immunity and longevity through ATFS‐1 and p38 signaling
por: Campos, Juliane C, et al.
Publicado: (2021)

Endosomal trafficking protein TBC-2 is required for the longevity of long-lived mitochondrial mutants
por: Traa, Annika, et al.
Publicado: (2023)

High confidence ATFS-1 target genes for quantifying activation of the mitochondrial unfolded protein response
por: Soo, Sonja K, et al.
Publicado: (2021)

Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways
por: Machiela, Emily, et al.
Publicado: (2020)

Mitochondrial thioredoxin system is required for enhanced stress resistance and extended longevity in long-lived mitochondrial mutants
por: Harris-Gauthier, Namastheé, et al.
Publicado: (2022)

Endosomal trafficking protein TBC‐2 modulates stress resistance and lifespan through DAF‐16‐dependent and independent mechanisms
por: Traa, Annika, et al.
Publicado: (2023)

Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies
por: Shields, Hazel J., et al.
Publicado: (2021)

Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson’s disease models
por: Cooper, Jason F., et al.
Publicado: (2017)

The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans
por: Peña, Salvador, et al.
Publicado: (2016)

The mitochondrial unfolded protein response (UPR(mt)) protects against osteoarthritis
por: Zhou, Zhibin, et al.
Publicado: (2022)

Loss of hif-1 promotes resistance to the exogenous mitochondrial stressor ethidium bromide in Caenorhabditis elegans
por: Kamal, Muntasir, et al.
Publicado: (2016)

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways
por: Wu, Ziyun, et al.
Publicado: (2018)

Environmental and Genetic Stressors and the Unfolded Protein Response in Exocrine Pancreatic Function – A Hypothesis
por: Pandol, Stephen J., et al.
Publicado: (2011)

The Mitochondrial Unfolded Protein Response: A Novel Protective Pathway Targeting Cardiomyocytes
por: Liu, Jinfeng, et al.
Publicado: (2022)

Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response
por: Kim, Eunah, et al.
Publicado: (2023)

The mitochondrial unfolded protein response (UPR(mt)): shielding against toxicity to mitochondria in cancer
por: Inigo, Joseph R., et al.
Publicado: (2022)

Describing and understanding behavioral responses to multiple stressors and multiple stimuli
por: Hale, Robin, et al.
Publicado: (2016)

Reconceptualizing synergism and antagonism among multiple stressors
por: Piggott, Jeremy J, et al.
Publicado: (2015)

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans
por: Van Raamsdonk, Jeremy M., et al.
Publicado: (2009)

The unfolded protein response in multiple sclerosis
por: Stone, Sarrabeth, et al.
Publicado: (2015)

Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics
por: Campos, Juliane Cruz, et al.
Publicado: (2023)

Decreased Mitochondrial Membrane Potential Activates the Mitochondrial Unfolded Protein Response
por: Berry, Brandon J., et al.
Publicado: (2021)

Folding Mitochondrial-Mediated Cytosolic Proteostasis Into the Mitochondrial Unfolded Protein Response
por: Jenkins, Edmund Charles, et al.
Publicado: (2021)

Exogenous Glutathione Protects IPEC-J2 Cells against Oxidative Stress through a Mitochondrial Mechanism
por: Chen, Qiuyu, et al.
Publicado: (2022)

Effect of the mitochondrial unfolded protein response on hypoxic death and mitochondrial protein aggregation
por: Yan, Junyi, et al.
Publicado: (2021)

The different axes of the mammalian mitochondrial unfolded protein response
por: Münch, Christian
Publicado: (2018)

Role of the membrane potential in mitochondrial protein unfolding and import
por: Sato, Takehiro K., et al.
Publicado: (2019)

Genetic players in multiple system atrophy: unfolding the nature of the beast
por: Stemberger, Sylvia, et al.
Publicado: (2011)

Oleuropein and rutin protect against 6-OHDA-induced neurotoxicity in PC12 cells through modulation of mitochondrial function and unfolded protein response
por: Elmazoglu, Zubeyir, et al.
Publicado: (2017)

TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response
por: Wang, Peng, et al.
Publicado: (2019)

Exogenous carbon monoxide protects against mitochondrial DNA-induced hippocampal pyroptosis in a model of hemorrhagic shock and resuscitation
por: Fu, Lan, et al.
Publicado: (2020)

Exogenous Hydrogen Sulfide Induces A375 Melanoma Cell Apoptosis Through Overactivation of the Unfolded Protein Response
por: Ma, Weiyuan, et al.
Publicado: (2023)

Enhancement of biocatalyst activity and protection against stressors using a microbial exoskeleton
por: Sakkos, Jonathan K., et al.
Publicado: (2019)

SESN2 protects against denervated muscle atrophy through unfolded protein response and mitophagy
por: Yang, Xiaofan, et al.
Publicado: (2021)

Mitochondrial unfolded protein response gene CLPP changes mitochondrial dynamics and affects mitochondrial function
por: Wu, GuiJun, et al.
Publicado: (2019)

Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection
por: Pellegrino, Mark W, et al.
Publicado: (2015)

The loss of LRPPRC function induces the mitochondrial unfolded protein response
por: Köhler, Fabian, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_9hs961nbpd068e7td6b0j81lnh