Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation

Cycling cells must respond to DNA double-strand breaks (DSBs) to avoid genome instability. Missegregation of chromosomes with DSBs during mitosis results in micronuclei, aberrant structures linked to disease. How cells respond to DSBs during mitosis is incompletely understood. We previously showed t...

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Detalles Bibliográficos
Autores principales: Clay, Delisa E., Bretscher, Heidi S., Jezuit, Erin A., Bush, Korie B., Fox, Donald T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500225/
https://www.ncbi.nlm.nih.gov/pubmed/34613334
http://dx.doi.org/10.1083/jcb.202106116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500225/
https://www.ncbi.nlm.nih.gov/pubmed/34613334
http://dx.doi.org/10.1083/jcb.202106116

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