Functional and metabolic fitness of human CD4(+) T lymphocytes during metabolic stress

Human CD4(+) T cells are essential mediators of immune responses. By altering the mitochondrial and metabolic states, we defined metabolic requirements of human CD4(+) T cells for in vitro activation, expansion, and effector function. T-cell activation and proliferation were reduced by inhibiting ox...

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Detalles Bibliográficos
Autores principales: Holthaus, Lisa, Sharma, Virag, Brandt, Daniel, Ziegler, Anette-Gabriele, Jastroch, Martin, Bonifacio, Ezio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500231/
https://www.ncbi.nlm.nih.gov/pubmed/34580176
http://dx.doi.org/10.26508/lsa.202101013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500231/
https://www.ncbi.nlm.nih.gov/pubmed/34580176
http://dx.doi.org/10.26508/lsa.202101013

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