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Functional and metabolic fitness of human CD4(+) T lymphocytes during metabolic stress

Human CD4(+) T cells are essential mediators of immune responses. By altering the mitochondrial and metabolic states, we defined metabolic requirements of human CD4(+) T cells for in vitro activation, expansion, and effector function. T-cell activation and proliferation were reduced by inhibiting ox...

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Detalles Bibliográficos
Autores principales:	Holthaus, Lisa, Sharma, Virag, Brandt, Daniel, Ziegler, Anette-Gabriele, Jastroch, Martin, Bonifacio, Ezio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500231/ https://www.ncbi.nlm.nih.gov/pubmed/34580176 http://dx.doi.org/10.26508/lsa.202101013

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