Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic

The COVID‐19 pandemic has forced clinical studies to accommodate imposed limitations. In this study, the bioequivalence part could not be conducted as planned. Thus, the aim was to demonstrate bioequivalence, using an adaptive study design, of tadalafil in fixed‐dose combination (FDC) tablets of mac...

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Detalles Bibliográficos
Autores principales: Csonka, Dénes, Fishman, Vladislav, Natarajan, Jaya, Stieltjes, Hans, Armas, Danielle, Dishy, Victor, Perez Ruixo, Juan Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500343/
https://www.ncbi.nlm.nih.gov/pubmed/34624174
http://dx.doi.org/10.1002/prp2.846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500343/
https://www.ncbi.nlm.nih.gov/pubmed/34624174
http://dx.doi.org/10.1002/prp2.846

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