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Leukemic progenitor cells enable immunosuppression and post-chemotherapy relapse via IL-36–inflammatory monocyte axis

Chemotherapy can effectively reduce the leukemic burden and restore immune cell production in most acute myeloid leukemia (AML) cases. Nevertheless, endogenous immunosurveillance usually fails to recover after chemotherapy, permitting relapse. The underlying mechanisms of this therapeutic failure ha...

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Detalles Bibliográficos
Autores principales: Guo, He-Zhou, Guo, Zi-Hua, Yu, Shan-He, Niu, Li-Ting, Qiang, Wan-Ting, Huang, Meng-Meng, Tian, Yuan-Yuan, Chen, Juan, Yang, Hui, Weng, Xiang-Qin, Zhang, Yi, Zhang, Wu, Hu, Shao-Yan, Shi, Jun, Zhu, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500518/
https://www.ncbi.nlm.nih.gov/pubmed/34623912
http://dx.doi.org/10.1126/sciadv.abg4167