Cargando…

NaCT/SLC13A5 facilitates citrate import and metabolism under nutrient-limited conditions

Citrate lies at a critical node of metabolism, linking tricarboxylic acid metabolism and lipogenesis via acetyl-coenzyme A. Recent studies have observed that deficiency of the sodium-dependent citrate transporter (NaCT), encoded by SLC13A5, dysregulates hepatic metabolism and drives pediatric epilep...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Avi, Cordes, Thekla, Thalacker-Mercer, Anna E., Pajor, Ana M., Murphy, Anne N., Metallo, Christian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500708/ https://www.ncbi.nlm.nih.gov/pubmed/34525352 http://dx.doi.org/10.1016/j.celrep.2021.109701

Ejemplares similares

Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)
por: Huard, Kim, et al.
Publicado: (2015)

Structure and inhibition mechanism of the human citrate transporter NaCT
por: Sauer, David B., et al.
Publicado: (2021)

The Hepatic Plasma Membrane Citrate Transporter NaCT (SLC13A5) as a Molecular Target for Metformin
por: Kopel, Jonathan, et al.
Publicado: (2020)

Functional analysis of a species-specific inhibitor selective for human Na(+)-coupled citrate transporter (NaCT/SLC13A5/mINDY)
por: Higuchi, Kei, et al.
Publicado: (2020)

Model‐Based Assessment of Plasma Citrate Flux Into the Liver: Implications for NaCT as a Therapeutic Target
por: Li, Z, et al.
Publicado: (2016)

Mapping the Metabolic Niche of Citrate Metabolism and SLC13A5
por: Chen, Fangfang, et al.
Publicado: (2023)

L-Arginine and Cardioactive Arginine Derivatives as Substrates and Inhibitors of Human and Mouse NaCT/Nact
por: Surrer, Daniela B., et al.
Publicado: (2022)

Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier
por: Kopel, Jonathan J., et al.
Publicado: (2021)

A home run for human NaCT/SLC13A5/INDY: cryo-EM structure and homology model to predict transport mechanisms, inhibitor interactions and mutational defects
por: Jaramillo-Martinez, Valeria, et al.
Publicado: (2021)

The NACT Training Package
por: Scarpello, John H. B.
Publicado: (1991)

Analysis of naturally occurring mutations in the human uptake transporter NaCT important for bone and brain development and energy metabolism
por: Selch, Stefan, et al.
Publicado: (2018)

Itaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase
por: Cordes, Thekla, et al.
Publicado: (2021)

The sodium-dependent di- and tricarboxylate transporter, NaCT, is not responsible for the uptake of D-, L-2-hydroxyglutarate and 3-hydroxyglutarate into neurons
por: Brauburger, Katja, et al.
Publicado: (2011)

NACT+IMRT versus NACT+IMRT+CCRT in locoregionally advanced NPC patients: a retrospective study
por: Chen, Xialin, et al.
Publicado: (2019)

A Novel and Cross-Species Active Mammalian INDY (NaCT) Inhibitor Ameliorates Hepatic Steatosis in Mice with Diet-Induced Obesity
por: Zahn, Grit, et al.
Publicado: (2022)

Plasma Membrane Na(+)-Coupled Citrate Transporter (SLC13A5) and Neonatal Epileptic Encephalopathy
por: Bhutia, Yangzom D., et al.
Publicado: (2017)

Importance of Nutrient Availability and Metabolism for Skeletal Muscle Regeneration
por: Blum, Jamie, et al.
Publicado: (2021)

Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury
por: Cordes, Thekla, et al.
Publicado: (2019)

The Role of GOLPH3L in the Prognosis and NACT response in Cervical Cancer
por: Feng, Yanling, et al.
Publicado: (2017)

Epilepsy and EEG Phenotype of SLC13A5 Citrate Transporter Disorder
por: Yang, Qian-Zhou, et al.
Publicado: (2020)

Correlation of clinicopathological outcomes with changes in IHC4 status after NACT in locally advanced breast cancers: do pre-NACT ER/PR status act as better prognosticators?
por: Chatterjee, Sanjoy, et al.
Publicado: (2015)

Growth and Overall Health of Patients with SLC13A5 Citrate Transporter Disorder
por: Brown, Tanya L., et al.
Publicado: (2021)

The citrate transporters SLC13A5 and SLC25A1 elicit different metabolic responses and phenotypes in the mouse
por: Fernandez-Fuente, Gonzalo, et al.
Publicado: (2023)

Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT
por: Zhu, Haiyan, et al.
Publicado: (2019)

Oncologic safety of breast conservation following NACT in women with locally advanced breast cancer
por: Agrawal, Sanjit Kumar, et al.
Publicado: (2023)

The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond
por: Mosaoa, Rami, et al.
Publicado: (2021)

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells
por: Badur, Mehmet G., et al.
Publicado: (2018)

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells
por: Badur, Mehmet G., et al.
Publicado: (2018)

Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span
por: Sessions, Ayla O., et al.
Publicado: (2018)

NTFD—a stand-alone application for the non-targeted detection of stable isotope-labeled compounds in GC/MS data
por: Hiller, Karsten, et al.
Publicado: (2013)

1-Deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells
por: Cordes, Thekla, et al.
Publicado: (2022)

Charting oncogenicity of genes and variants across lineages via multiplexed screens in teratomas
por: Parekh, Udit, et al.
Publicado: (2021)

Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress
por: Kuna, Ramya S., et al.
Publicado: (2023)

“This house believes that: Sentinel node biopsy alone is better than TAD after NACT for cN+ patients”
por: Galimberti, Viviana, et al.
Publicado: (2022)

SLC kicker magnet limitations
por: Cassel, R L, et al.
Publicado: (1991)

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
por: Koppula, Pranavi, et al.
Publicado: (2020)

Mutations in the Mitochondrial Citrate Carrier SLC25A1 are Associated with Impaired Neuromuscular Transmission
por: Chaouch, Amina, et al.
Publicado: (2014)

Reliability and Validity of Physical Function Tests and ADL Survey Questions in Females Living in Rural, Highland Ethiopia
por: Golan, Jenna, et al.
Publicado: (2022)

Cost-effectiveness and resource use of implementing MRI-guided NACT in ER-positive/HER2-negative breast cancers in The Netherlands
por: Miquel-Cases, Anna, et al.
Publicado: (2016)

Molecular Mechanism of Citrate Efflux by the Mitochondrial Citrate Transporter CT in Filamentous Fungus Mucor circinelloides WJ11
por: Yang, Wu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i2cjhvhtg90hblq76cb2sks4q9