SHP-2 deletion in CD4Cre expressing chondrocyte precursors leads to tumor development with wrist tropism

Due to redundancy with other tyrosine phosphatases, the ubiquitously expressed tyrosine phosphatase SHP-2 (encoded by Ptpn11) is not required for T cell development. However, Ptpn11 gene deletion driven by CD4 Cre recombinase leads to cartilage tumors in the wrist. Using a fate mapping system, we de...

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Detalles Bibliográficos
Autores principales: McNamara, Jeffrey T., Huntington, Kelsey E., Borys, Samantha, Jayasuriya, Chathuraka T., Brossay, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501018/
https://www.ncbi.nlm.nih.gov/pubmed/34625577
http://dx.doi.org/10.1038/s41598-021-99339-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501018/
https://www.ncbi.nlm.nih.gov/pubmed/34625577
http://dx.doi.org/10.1038/s41598-021-99339-0

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