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SHP-2 deletion in CD4Cre expressing chondrocyte precursors leads to tumor development with wrist tropism
Due to redundancy with other tyrosine phosphatases, the ubiquitously expressed tyrosine phosphatase SHP-2 (encoded by Ptpn11) is not required for T cell development. However, Ptpn11 gene deletion driven by CD4 Cre recombinase leads to cartilage tumors in the wrist. Using a fate mapping system, we de...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501018/ https://www.ncbi.nlm.nih.gov/pubmed/34625577 http://dx.doi.org/10.1038/s41598-021-99339-0 |