CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression

Immune cells at sites of inflammation are continuously activated by local antigens and cytokines, and regulatory mechanisms must be enacted to control inflammation. The stepwise hydrolysis of extracellular ATP by ectonucleotidases CD39 and CD73 generates adenosine, a potent immune suppressor. Here w...

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Detalles Bibliográficos
Autores principales: Schneider, Enja, Winzer, Riekje, Rissiek, Anne, Ricklefs, Isabell, Meyer-Schwesinger, Catherine, Ricklefs, Franz L., Bauche, Andreas, Behrends, Jochen, Reimer, Rudolph, Brenna, Santra, Wasielewski, Hauke, Lauten, Melchior, Rissiek, Björn, Puig, Berta, Cortesi, Filippo, Magnus, Tim, Fliegert, Ralf, Müller, Christa E., Gagliani, Nicola, Tolosa, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501027/
https://www.ncbi.nlm.nih.gov/pubmed/34625545
http://dx.doi.org/10.1038/s41467-021-26134-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501027/
https://www.ncbi.nlm.nih.gov/pubmed/34625545
http://dx.doi.org/10.1038/s41467-021-26134-w

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