Dysregulated APOBEC3G causes DNA damage and promotes genomic instability in multiple myeloma

Multiple myeloma (MM) is a heterogeneous disease characterized by significant genomic instability. Recently, a causal role for the AID/APOBEC deaminases in inducing somatic mutations in myeloma has been reported. We have identified APOBEC/AID as a prominent mutational signature at diagnosis with fur...

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Detalles Bibliográficos
Autores principales: Talluri, Srikanth, Samur, Mehmet K., Buon, Leutz, Kumar, Subodh, Potluri, Lakshmi B., Shi, Jialan, Prabhala, Rao H., Shammas, Masood A., Munshi, Nikhil C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501035/
https://www.ncbi.nlm.nih.gov/pubmed/34625538
http://dx.doi.org/10.1038/s41408-021-00554-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501035/
https://www.ncbi.nlm.nih.gov/pubmed/34625538
http://dx.doi.org/10.1038/s41408-021-00554-9

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