Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

Parkinson’s disease and related synucleinopathies are characterized by the abnormal accumulation of alpha-synuclein aggregates, loss of dopaminergic neurons, and gliosis of the substantia nigra. Although clinical evidence and in vitro studies indicate disruption of the Blood-Brain Barrier in Parkins...

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Detalles Bibliográficos
Autores principales: Pediaditakis, Iosif, Kodella, Konstantia R., Manatakis, Dimitris V., Le, Christopher Y., Hinojosa, Chris D., Tien-Street, William, Manolakos, Elias S., Vekrellis, Kostas, Hamilton, Geraldine A., Ewart, Lorna, Rubin, Lee L., Karalis, Katia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501050/
https://www.ncbi.nlm.nih.gov/pubmed/34625559
http://dx.doi.org/10.1038/s41467-021-26066-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501050/
https://www.ncbi.nlm.nih.gov/pubmed/34625559
http://dx.doi.org/10.1038/s41467-021-26066-5

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