An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma

Oncolytic herpes simplex virus-1 is capable of lysing tumor cells while alerting the immune system. CD47, in collaboration with SIRPα, represents an important immune checkpoint to inhibit phagocytosis by innate immune cells. Here we show locoregional control of glioblastoma by an oncolytic herpes vi...

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Detalles Bibliográficos
Autores principales: Xu, Bo, Tian, Lei, Chen, Jing, Wang, Jing, Ma, Rui, Dong, Wenjuan, Li, Aimin, Zhang, Jianying, Antonio Chiocca, E., Kaur, Balveen, Feng, Mingye, Caligiuri, Michael A., Yu, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501058/
https://www.ncbi.nlm.nih.gov/pubmed/34625564
http://dx.doi.org/10.1038/s41467-021-26003-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501058/
https://www.ncbi.nlm.nih.gov/pubmed/34625564
http://dx.doi.org/10.1038/s41467-021-26003-6

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