An interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation

The mitochondrial uncoupling protein 2 (UCP2) plays a protective function in the vascular disease of both animal models and humans. UCP2 downregulation upon high-salt feeding favors vascular dysfunction in knock-out mice, and accelerates cerebrovascular and renal damage in the stroke-prone spontaneo...

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Detalles Bibliográficos
Autores principales: Forte, Maurizio, Bianchi, Franca, Cotugno, Maria, Marchitti, Simona, Stanzione, Rosita, Maglione, Vittorio, Sciarretta, Sebastiano, Valenti, Valentina, Carnevale, Roberto, Versaci, Francesco, Frati, Giacomo, Volpe, Massimo, Rubattu, Speranza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501098/
https://www.ncbi.nlm.nih.gov/pubmed/34625529
http://dx.doi.org/10.1038/s41419-021-04188-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501098/
https://www.ncbi.nlm.nih.gov/pubmed/34625529
http://dx.doi.org/10.1038/s41419-021-04188-4

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