OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice

Linear ubiquitination regulates inflammatory and cell death signalling. Deficiency of the linear ubiquitin chain-specific deubiquitinase, OTULIN, causes OTULIN-related autoinflammatory syndrome (ORAS), a systemic inflammatory pathology affecting multiple organs including the skin. Here we show that...

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Detalles Bibliográficos
Autores principales: Schünke, Hannah, Göbel, Ulrike, Dikic, Ivan, Pasparakis, Manolis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501112/
https://www.ncbi.nlm.nih.gov/pubmed/34625557
http://dx.doi.org/10.1038/s41467-021-25945-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501112/
https://www.ncbi.nlm.nih.gov/pubmed/34625557
http://dx.doi.org/10.1038/s41467-021-25945-1

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