APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer’s disease

Genome-wide association studies (GWAS) have identified polymorphism in the Apolipoprotein E gene (APOE) to be the most prominent risk factor for Alzheimer’s disease (AD). Compared to individuals homozygous for the APOE3 variant, individuals with the APOE4 variant have a significantly elevated risk o...

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Detalles Bibliográficos
Autores principales: Brookhouser, Nicholas, Raman, Sreedevi, Frisch, Carlye, Srinivasan, Gayathri, Brafman, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501163/
https://www.ncbi.nlm.nih.gov/pubmed/33837271
http://dx.doi.org/10.1038/s41380-021-01076-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501163/
https://www.ncbi.nlm.nih.gov/pubmed/33837271
http://dx.doi.org/10.1038/s41380-021-01076-3

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