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APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer’s disease

Genome-wide association studies (GWAS) have identified polymorphism in the Apolipoprotein E gene (APOE) to be the most prominent risk factor for Alzheimer’s disease (AD). Compared to individuals homozygous for the APOE3 variant, individuals with the APOE4 variant have a significantly elevated risk o...

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Detalles Bibliográficos
Autores principales:	Brookhouser, Nicholas, Raman, Sreedevi, Frisch, Carlye, Srinivasan, Gayathri, Brafman, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501163/ https://www.ncbi.nlm.nih.gov/pubmed/33837271 http://dx.doi.org/10.1038/s41380-021-01076-3

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