Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL(pro) substrate degradome

The main viral protease (3CL(pro)) is indispensable for SARS-CoV-2 replication. We delineate the human protein substrate landscape of 3CL(pro) by TAILS substrate-targeted N-terminomics. We identify more than 100 substrates in human lung and kidney cells supported by analyses of SARS-CoV-2-infected c...

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Detalles Bibliográficos
Autores principales: Pablos, Isabel, Machado, Yoan, de Jesus, Hugo C. Ramos, Mohamud, Yasir, Kappelhoff, Reinhild, Lindskog, Cecilia, Vlok, Marli, Bell, Peter A., Butler, Georgina S., Grin, Peter M., Cao, Quynh T., Nguyen, Jenny P., Solis, Nestor, Abbina, Srinivas, Rut, Wioletta, Vederas, John C., Szekely, Laszlo, Szakos, Attila, Drag, Marcin, Kizhakkedathu, Jayachandran N., Mossman, Karen, Hirota, Jeremy A., Jan, Eric, Luo, Honglin, Banerjee, Arinjay, Overall, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501228/
https://www.ncbi.nlm.nih.gov/pubmed/34672947
http://dx.doi.org/10.1016/j.celrep.2021.109892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501228/
https://www.ncbi.nlm.nih.gov/pubmed/34672947
http://dx.doi.org/10.1016/j.celrep.2021.109892

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