Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells

BACKGROUND: Identification of genomic biomarkers to predict the anticancer effects of indicated drugs is considered a promising strategy for the development of precision medicine. DNA endonuclease MUS81 plays a pivotal role in various biological processes during malignant diseases, mainly in DNA dam...

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Detalles Bibliográficos
Autores principales: Li, Chengguo, Shen, Qian, Zhang, Peng, Wang, Tao, Liu, Weizhen, Li, Ruidong, Ma, Xianxiong, Zeng, Xiangyu, Yin, Yuping, Tao, Kaixiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501558/
https://www.ncbi.nlm.nih.gov/pubmed/34625086
http://dx.doi.org/10.1186/s13046-021-02120-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501558/
https://www.ncbi.nlm.nih.gov/pubmed/34625086
http://dx.doi.org/10.1186/s13046-021-02120-4

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