Cargando…

Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells

BACKGROUND: Identification of genomic biomarkers to predict the anticancer effects of indicated drugs is considered a promising strategy for the development of precision medicine. DNA endonuclease MUS81 plays a pivotal role in various biological processes during malignant diseases, mainly in DNA dam...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Chengguo, Shen, Qian, Zhang, Peng, Wang, Tao, Liu, Weizhen, Li, Ruidong, Ma, Xianxiong, Zeng, Xiangyu, Yin, Yuping, Tao, Kaixiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501558/ https://www.ncbi.nlm.nih.gov/pubmed/34625086 http://dx.doi.org/10.1186/s13046-021-02120-4

Ejemplares similares

MUS81 Inhibition Enhances the Anticancer Efficacy of Talazoparib by Impairing ATR/CHK1 Signaling Pathway in Gastric Cancer
por: Wang, Tao, et al.
Publicado: (2022)

Metformin promotes cGAS/STING signaling pathway activation by blocking AKT phosphorylation in gastric cancer
por: Shen, Qian, et al.
Publicado: (2023)

Combination of PARP inhibitor and CDK4/6 inhibitor modulates cGAS/STING‐dependent therapy‐induced senescence and provides “one‐two punch” opportunity with anti‐PD‐L1 therapy in colorectal cancer
por: Wang, Tao, et al.
Publicado: (2023)

cGAS/STING: novel perspectives of the classic pathway
por: Gao, Menghui, et al.
Publicado: (2020)

Novel insights into maintaining genomic integrity: Wee1 regulating Mus81/Eme1
por: Martín, Yusé, et al.
Publicado: (2011)

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease
por: Domínguez-Kelly, Raquel, et al.
Publicado: (2011)

4-Octyl itaconate regulates immune balance by activating Nrf2 and negatively regulating PD-L1 in a mouse model of sepsis
por: Zhang, Peng, et al.
Publicado: (2022)

The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability
por: Hong, Christy, et al.
Publicado: (2019)

The Role of cGAS-STING in Age-Related Diseases from Mechanisms to Therapies
por: Zheng, Weitao, et al.
Publicado: (2023)

cGAS-STING pathway in cancer biotherapy
por: Wang, Yang, et al.
Publicado: (2020)

Mitotic inactivation of the cGAS‒MITA/STING pathways
por: Zhong, Li, et al.
Publicado: (2021)

Significance of the cGAS-STING Pathway in Health and Disease
por: Zhou, Jinglin, et al.
Publicado: (2023)

Attenuation of cGAS/STING activity during mitosis
por: Uhlorn, Brittany L, et al.
Publicado: (2020)

cGAS-STING, an important pathway in cancer immunotherapy
por: Jiang, Minlin, et al.
Publicado: (2020)

BRD4 Inhibitor AZD5153 Suppresses the Proliferation of Colorectal Cancer Cells and Sensitizes the Anticancer Effect of PARP Inhibitor
por: Zhang, Peng, et al.
Publicado: (2019)

BRD4 Inhibitor AZD5153 Suppresses the Proliferation of Colorectal Cancer Cells and Sensitizes the Anticancer Effect of PARP Inhibitor: Erratum
por: Zhang, Peng, et al.
Publicado: (2022)

Telomere recombination requires the MUS81 endonuclease
por: Zeng, Sicong, et al.
Publicado: (2009)

The pleiotropic roles of cGAS–STING signaling in the tumor microenvironment
por: Li, Jun, et al.
Publicado: (2022)

cGAS-STING pathway in oncogenesis and cancer therapeutics
por: Hoong, Brandon Yi Da, et al.
Publicado: (2020)

The interactions between cGAS-STING pathway and pathogens
por: Cheng, Zhangliang, et al.
Publicado: (2020)

The Complexity of the cGAS-STING Pathway in CNS Pathologies
por: Fryer, Amelia L., et al.
Publicado: (2021)

The role of cGAS-STING signalling in liver diseases
por: Chen, Ruihan, et al.
Publicado: (2021)

Advances in cGAS-STING Signaling Pathway and Diseases
por: Yang, Yuting, et al.
Publicado: (2022)

Telomere Maintenance and the cGAS-STING Pathway in Cancer
por: Ebata, Hiroshi, et al.
Publicado: (2022)

Intercellular transmission of cGAS-STING signaling in cancer
por: Wu, Qirou, et al.
Publicado: (2023)

Role of cGAS–Sting Signaling in Alzheimer’s Disease
por: Govindarajulu, Manoj, et al.
Publicado: (2023)

The Activation of cGAS-STING in Acute Kidney Injury
por: Sun, Chuanchuan, et al.
Publicado: (2023)

Targeting the loss of cGAS/STING signaling in cancer
por: Sasaki, Nobunari, et al.
Publicado: (2023)

cGAS-STING triggers inflammaging-associated neurodegeneration
por: Izquierdo, José M.
Publicado: (2023)

4-OI Attenuates Carbon Tetrachloride-Induced Hepatic Injury via Regulating Oxidative Stress and the Inflammatory Response
por: Li, Ruidong, et al.
Publicado: (2021)

The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer
por: Mohseni, Ghazal, et al.
Publicado: (2021)

cGAS-STING signaling pathway in intestinal homeostasis and diseases
por: Yang, Yuchen, et al.
Publicado: (2023)

cGAS/STING signaling in the regulation of rheumatoid synovial aggression
por: Li, Ruiru, et al.
Publicado: (2022)

Chikungunya virus antagonizes cGAS-STING mediated type-I interferon responses by degrading cGAS
por: Webb, L. G., et al.
Publicado: (2020)

Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy
por: Zheng, Juyan, et al.
Publicado: (2020)

The cGAS/STING Pathway: A Novel Target for Cancer Therapy
por: Gan, Yu, et al.
Publicado: (2022)

The cGAS-STING Defense Pathway and Its Counteraction by Viruses
por: Ma, Zhe, et al.
Publicado: (2016)

cGAS-independent STING activation in response to DNA damage
por: Unterholzner, Leonie, et al.
Publicado: (2019)

Conserved strategies for pathogen evasion of cGAS–STING immunity
por: Eaglesham, James B, et al.
Publicado: (2020)

The cGAS-STING Pathway in Hematopoiesis and Its Physiopathological Significance
por: Liao, Weinian, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_b4hiq3d9e36b8379qjqburnhnd